Biology and Pathology of the Oocyte - Role in Fertility and Reproductive Medicine

Trounson - Biology and Pathology of the Oocyte
£88.00
£88.00
Authors/editors: Alan O Trounson and Roger G Gosden
ISBN: 978-0-521-79958-4
Page count: 350
Publisher: Cambridge UP
Publication year: 2003

The human oocyte or egg is the rarest and most rapidly ageing cell in the body, and yet one that is essential for fertility. This book is about the development, biology and pathology of the oocyte, and new technologies to manipulate, enhance, and control fertility. These technologies are paving the way for overcoming infertility, avoiding inherited diseases, and creating genetically engineered animals from embryo stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book, including the ability to manipulate and fertilize oocytes in vitro. World-leading experts have contributed to the first book for many years on basic and applied science of the egg, its clinical manipulation, and its pivotal role in reproductive medicine and biology. It will be an essential reference for scientists and clinicians in reproductive medicine and animal breeding technology, and everyone involved in treating infertility.

Table of contents:

Part I. Historical Perspective:
1. The magic and mystery of the oocyte: ex ovo omnia

Part II. Life Cycle
2. Ontogeny of the mammalian ovary
3. The early stages of follicle growth
4. Modelling the dynamics of ovarian follicle utilisation throughout life
5. Comparative aspects of oogenesis

Part III. Developmental Biology
6. Oocyte-specific gene expression: roles in folliculogenesis, fertilization and early development
7. Morphology and pathology of the human oocyte
8. Storage and functional recovery of molecules in oocytes
9. Endocrine regulation of meiosis - local and systemic hormonal influences
10. Checkpoint controls in mammalian oocytes
11. Fertilization: fate of sperm components after ICSI
12. Activation of the mammalian egg
13. Clinical application of symmetry, asymmetry and polarity in early human development

Part IV. Pathology:
14. The legacy of mitochondrial DNA
15. Aneuploidy in ageing oocytes and after toxic insult
16. Genetic basis of primary ovarian failure
17. Growth and development of the mammalian oocyte-granulosa cell complex in culture
18. Human oocyte maturation in vitro
19. Follicular factors affecting oocyte maturation and development competence
20. Low temperature storage of follicular and ovulated oocytes
21. Fecundity of transplanted ovaries

Categories

main menu