Implantation and Early Development

Critchley - Implantation and Early Development
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£6.00
Authors/editors: Hilary Critchley, Iain Cameron and Stephen Smith
ISBN: 978-1-904752-16-5
Page count: 304
Publisher: RCOG Press
Publication year: 2005

Reduced from £52.00 retail price/£39.00 RCOG members price

Successful implantation and early development need a union of healthy genes and an optimal uterine environment. The 48th RCOG Study Group, an international multidisciplinary expert forum, considered factors involved in preparation for implantation within the uterus, what makes a good egg and sperm and hence a good embryo. Lessons from animal models and transgenic and genomic technologies considered. The group looked at sporadic and recurrent early pregnancy loss and discussed new treatment options. Discussion also included single-embryo transfer and the developmental consequences of assisted reproduction technologies.

This publication provides a valuable resource for gynaecologists, specialist nurses, embryologists, base scientists and all those with an interest in early pregnancy and development.

Reduced from £52.00 retail price/£39.00 RCOG members price

Table of contents:

Section 1 Preparation for Implantation – the Uterine Environment

  1. Endocrine and paracrine signaling in the human endometrium: potential role for the prostanoid family in implantation
  2. Immunology of implantation
  3. progestin-induced decidualisation promotes human endometrial haemostasis and vascular stability
  4. Adhesion molecules and implantation
  5. Vascular growth and modeling in the endometrium
  6. Tissue remodeling at the fetal-maternal interface: the regulation of matrix metalloproteinase 9 transcriptase.
  7. Embryo interactions in human implantation
  8. Experimental models of implantation of the human embryo: reconstruction the endometrial-embryo dialogue in vitro

Section 2 The Embryo

  1. What makes a good egg?
  2. What makes ‘good sperm’?
  3. Morphogenesis of the early mammalian embryo: cell lineage heterogeneity and developmental potential
  4. Epigenetics in development and cloning by nuclear transfer: alternative approaches to nuclear reprogramming
  5. Risks associated with assisted reproduction: insights from animal studies
  6. Pre-implantation genetic testing

Section 3 Lessons from Animal Models (Transgenics) and Novel Technologies

  1. To implant or not to implant: the role of leukaemia inhibitory factor
  2. Are gene arrays useful for the study of implantation?

Section 4 Clinical Sequelae

  1. Sporadic early pregnancy loss: aetiology and management
  2. Recurrent miscarriage – the role of prothrombotic disorders
  3. Reproductive disorders and pregnancy outcome
  4. Risk factors for first-trimester miscarriage: summary of results from the National Women’s Health Study
  5. Single-embryo transfer
  6. Paediatric outcome after assisted reproductive technology

Section 5 Consensus Views

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