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£112.50 (discounted from £125.00)
£112.50
ISBN: 978-0-415-39227-3
Page count: 204
Publisher: Informa
Publication year: 2007
Preterm delivery is probably the most important problem in obstetrics, and a major public health concern. Recent developments - such as the preventive use of progesterone, and new data on possible mechanisms of initiation of parturition – have placed the topic at the forefront of the interests and preoccupation of many in maternal-fetal medicine and obstetrics.
Recent studies have found that preterm deliveries have increased even amongst low risk women. Also shown is that assisted conceptions, multiple pregnancies and elective deliveries are associated with early birth. The impact on society is considerable. Preterm birth can also have considerable impact on long-term health, including severe mental or physical disability. With all this being currently debated, Obstetricians should re-evaluate the risks and benefits of delivering babies earlier.
This book, published in collaboration with the Society for Gynecologic Investigation, is a balanced, authoritative, well-referenced work with a rigorous underpinning of basic science and evidence-based clinical guidelines. The editors have ensured that there is development of modern ideas throughout regarding understanding, research, prevention and treatment of preterm birth.
Table of contents:
Section 1 – Mechanisms
1. Myometrial programming – a new concept underlying the regulation of myometrial function during pregnancy
2. Cervical function during pregnancy and parturition
3. Endocrine and paracrine mechanisms in human placenta and fetal membranes
4. Stress and the pathophysiology of human birth
Section 2 – Mediators
5. Undernutrition, preterm birth and the prostaglandin pathway
6. Gene redundancy in parturition: lessons for tocolysis?
7. Regulation of inflammatory response pathways during pregnancy and labor
8. Matrix biology and preterm birth
9. Nitric oxide
10. Relaxin-related preterm birth
Section 3 – Methods of prediction and prevention
11. Biochemical markers of preterm delivery
12. Biophysical methods of prediction and prevention of preterm labor: uterine electromyography and cervical light-induced fluorescence – new obstetrical diagnostic techniques
13. Genetics of preterm delivery
Section 4 – Current status of interventions
14. Calcium-channel blockers and betamimetics
15. Prostaglandins, oxytocin and antagonists
16. Progestational agents and labor
17. Antenatal corticosteroid treatment
18. Monitoring the growth-restricted fetus during the preterm period


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