Introduction to malignant disease of the uterus

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Endometrial cancer is considered to be relatively less aggressive when compared with other gynaecological malignancies. Many women will have been treated effectively with a simple hysterectomy and bilateral oopherectomy in a non-cancer centre setting, and may have falsely regarded this cancer as fairly benign. However, stage for stage, survival is comparable to other gynaecological malignancies.

Patients have tended to do better because it is possible to detect the disease at an earlier stage (because of postmenopausal bleeding). Several controversies still remain in this field, and the roles of lymphadenectomy, radiotherapy and chemotherapy still remain to be defined. Practitioners must continue to be vigilant in identifying this very treatable cancer.

Learning objectives

When you have completed this tutorial, you should be able to:

  • identify women with risk factors for endometrial cancer
  • know the relative risk of endometrial cancer
  • understand the various methods of investigating postmenopausal bleeding
  • understand the value of staging and the treatment modalities for the various stages
  • comprehend the significance of the different types of pathology of the hyperplasia and the cancers

Last updated: 10/06/2011 (The section on fallopian tube cancer and associated assessments were moved from this tutorial to Malignant disease of the ovary and fallopian tube)

20/01/11 (Tutorial revised and updated by Dr Kenneth Lim)

30/11/09 (revised FIGO cancer staging incorporated into the tutorial by Dr Nick Wood. See the FIGO staging of carcinoma of the endometrium and FIGO staging of uterine sarcomas sections for the FIGO staging tables)


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