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Introduction to pre-invasive disease of the lower genital tract

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Normal cervix.

Pre-invasive disease of the female lower genital tract encompasses a spectrum of intraepithelial neoplasia of the cervix, vulva and vagina. These changes are referred to as cervical, vulval and vaginal intraepithelial neoplasia (CIN, VIN and VAIN, respectively).

Learning objectives

When you have completed this tutorial, you should:

  • understand the basic anatomy and histology of the cervix
  • understand the concept of pre-invasive disease
  • gain basic knowledge of the biology of human papillomavirus
  • recognise the benefit of screening for pre-invasive disease
  • understand the treatment of pre-invasive disease
  • understand the benefits and limitations of immunisation against HPV disease

Last updated:03/02/11 (tutorial was reviewed and updated)

02/04/09 (research paper added in the HPV – Further reading section)

16/03/09 (BJOG paper added in the HPV – The vacciantion scheme and objections and Further reading sections).

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