Question: In a 50 year old with stage 1C Granulosa cell tumour, ascitic fluid negative but spontaneous rupture. No residual disease. Adjuvant chemotherapy or no chemotherapy?
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Answer: Three recent reviews report that there are no clear conclusions regarding the role of postoperative chemotherapy in stage I disease, although the use of adjuvant chemotherapy or radiotherapy has sometimes been associated with prolonged disease-free survival and possibly overall survival (Geetha, Koukourakis, Pectasides). No more recent studies were identified.
Tumour rupture is a risk factor for recurrence (Geetha).
A protocol for a Cochrane review of different treatment modalities for the management of adult onset granulosa cell tumours of the ovary has been published (Shanbhag).
References:
- Geetha P, Nair MK. Granulosa cell tumours of the ovary. Aust N Z J Obstet Gynaecol. 2010 Jun;50(3):216-20 Abstract
- Koukourakis GV. Kouloulias VE. Koukourakis MJ. Zacharias GA. Papadimitriou C. Mystakidou K. Pistevou-Gompaki K. Kouvaris J. Gouliamos A. Granulosa cell tumor of the ovary: tumor review. [Review] [99 refs] Integrative Cancer Therapies. 7(3):204-15, 2008 Sep. Abstract
- Pectasides D. Pectasides E. Psyrri A. Granulosa cell tumor of the ovary. [Review] [99 refs] Cancer Treatment Reviews. 34(1):1-12, 2008 Feb. Abstract
Other references:
- Shanbhag S, Cairns M, Cruickshank M, Dickinson HO, Gokul S, Parkin D. Effectiveness of different treatment modalities for the management of adult onset granulosa cell tumours of the ovary (primary and recurrent) (Protocol). Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD006912. DOI: 10.1002/14651858.CD006912.
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Search date: December 2010
