This guideline replaces The Management of Gestational Trophoblastic Disease, issued in April 1999 as Guideline No. 18.
Gestational trophoblastic neoplasia (GTN) (hydatidiform mole, invasive mole, choriocarcinoma, placental site trophoblastic tumour) is a rare event in the UK, with a calculated incidence of 1/714 live births. There is evidence of ethnic variation in the incidence of GTN in the UK, with women from Asia having a higher incidence compared with non-Asian women (1/387 versus 1/752 live births). However, this may under-represent the true incidence of the disease because of problems with reporting, particularly with regard to partial moles. Persistent GTN may develop after a molar pregnancy, a nonmolar pregnancy or a live birth. The incidence after a live birth is estimated at 1/50 000.Because of the rarity of the problem, an average consultant may deal with only one new case every second year. The purpose of this guideline is to provide guidance on the management of women with GTN in the UK.
This guideline is can be downloaded as a pdf using the link below.
