Question:
What is the risk of cervical cancer in a woman with a smear showing mild dyskaryosis with normal and adequate/ satisfactory colposcopy in the age group of 20 - 25 and 25 -30 years?
Answer:
In a retrospective study of 2157 women with mild dyskariosis or borderline nuclear changes and normal initial colposcopy (1), high-grade or invasive disease was diagnosed histologically in 35.8% of 1352 women referred with mild dyskaryosis. Among 620 women with normal colposcopy and a negative or borderline repeat smear, high-grade disease was found after 5 years of follow up in 8.5% of women referred because of mild dyskaryosis. Age had no effect on these results. (Evidence level III)
Reference:
- A long-term study of women with normal colposcopy after referral with low-grade cytological abnormalities.[see comment]. Smith MC. Keech SE. Perryman K. Soutter WP. BJOG: An International Journal of Obstetrics & Gynaecology. 113(11):1321-8, 2006 Nov. Full text available to Fellows and Members. Abstract
Search date: December 2009
Classification of evidence levels
Ia Evidence obtained from meta-analysis of randomised controlled trials.
Ib Evidence obtained from at least one randomised controlled trial.
IIa Evidence obtained from at least one well-designed controlled study without randomisation.
IIb Evidence obtained from at least one other type of well-designed quasi-experimental study.
III Evidence obtained from well-designed non-experimental descriptive studies, such as comparative studies, correlation studies and case studies.
IV Evidence obtained from expert committee reports or opinions and/or clinical experience of respected authorities.
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