Question: 52 yr old with turners syndrome - not on HRT. Was due to have routine smear and noted to have hypertrophic vagina.
Is turners syndrome associated with vaginal hyperplasia/neoplasia?
Does she require laparoscopy to exclude any streak ovaries ?
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Answer: Two case reports of vaginal neoplasms were found in women with gonadal dysgenesis (1,2)
Two national cohort studies of cancer incidence in women with Turner syndrome (3,4) were identified. Only the abstracts of these papers are immediately available to the Library, but neither mention cancer of the vagina. (Evidence level III)
No information was found on investigations indicated in women with Turner syndrome and hypertrophic vagina.
References:
- Resnik E. Christopherson WA. Stock R. Clear cell adenocarcinoma of the cervix and vagina in a woman with mixed gonadal dysgenesis. A case report. Journal of Reproductive Medicine. 34(12):981-4, 1989 Dec. Abstract
- Shingleton HM. Younger JB. Beasley WE. Levy D. Gore H. Lawrence WD. Adenocarcinoma of the vagina in a patient with gonadal dysgenesis. Obstetrics & Gynecology. 53(3 Suppl):92S-97S, 1979 Mar. Abstract
- Schoemaker MJ. Swerdlow AJ. Higgins CD. Wright AF. Jacobs PA. UK Clinical Cytogenetics Group. Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study. Lancet Oncology. 9(3):239-46, 2008 Mar. Abstract
- Hasle H. Olsen JH. Nielsen J. Hansen J. Friedrich U. Tommerup N. Occurrence of cancer in women with Turner syndrome. British Journal of Cancer. 73(9):1156-9, 1996 May. Abstract
Search date: May 2009
Classification of evidence levels
Ia Evidence obtained from meta-analysis of randomised controlled trials.
Ib Evidence obtained from at least one randomised controlled trial.
IIa Evidence obtained from at least one well-designed controlled study without randomisation.
IIb Evidence obtained from at least one other type of well-designed quasi-experimental study.
III Evidence obtained from well-designed non-experimental descriptive studies, such as comparative studies, correlation studies and case studies.
IV Evidence obtained from expert committee reports or opinions and/or clinical experience of respected authorities.
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