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3.3 Genomics in oncology

These resources have been reviewed by a panel of consultants and trainees. Quotes have been provided by this panel.

 

3.3.1 Genomics and cancer care

Video 4min

How genomics is used in cancer care. Improved technologies, increased understanding of genomic data, and the increased availability and affordability of testing, have all brought changes to the way in which patients and their families are treated and cared for. As genomics becomes embedded into routine care, it's important that all gynaecologists have an understanding of where genomics may be relevant and how to manage and base decisions on genomic data. 

“Excellent summary of how genomics can inform personalised risk prediction and target treatments in cancer care.”

https://vimeo.com/309285996

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3.3.2 The Realisation of Personalised Medicine

Video 3min

This short video from HEE describes exciting developments in the analysis of mutational signatures in tumour DNA. It demonstrates how genomic testing can provide a useful picture of the mutational signature of an individual’s cancer, which can enable the detection of inherited cancer susceptibility genes which might impact on treatment and management. 

“Really good summary of germline versus somatic genomics and how this is important for personalised medicine.”
“Accessible and well presented.”

https://vimeo.com/336816796

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3.3.3 Interpretation of variants of uncertain significance (VUS)

Video 3min

A short video with a case study exemplifying the dangers of poor interpretation of genomic results for individuals and their families and the concept of variants of uncertain significance. It outlines the importance of exercising caution when reporting genomic variants.

“Good summary and accessible – useful to have the clinical relevance to drive the point home.”

https://vimeo.com/336813135

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3.3.4 Tumour immunology and immunotherapy

Video 5min animation

This animation illustrates how tumour cells are sensed and destroyed by cells of the immune system; how tumours can evolve to evade immune-mediated elimination; and how some immunotherapies are designed to help the immune system ‘fight back’. 

“A good summary of a complicated subject. Really interesting for a trainee in GynOnc.”

 

https://www.youtube.com/watch?v=K09xzIQ8zsg

 

3.3.5 Immunotherapy: Boosting the immune system to fight cancer

Video 8min animation

Presentation from Nature dealing with the different approaches that are being investigated to harness the immune system to treat cancer. This video supplements 3.2.4.

https://www.youtube.com/watch?v=-NNjDjXSJt0

 

3.3.6 Lynch syndrome for the gynaecologist

Article – The Obstetrician and Gynaecologist (TOG)

https://obgyn.onlinelibrary.wiley.com/doi/10.1111/tog.12706

Learn the pathogenesis of Lynch Syndrome and its associated gynaecological cancers, and learn how best to counsel women with Lynch syndrome regarding cancer and risk-reducing strategies.

Simple infographic from TOG showing the percentage maximum risk of different types of cancers in female people at 75 years of age

Ryan NAJ, McMahon RFT, Ramchander NC, Seif MW, Evans DG, Crosbie EJ. Lynch syndrome for the gynaecologist. The Obstetrician & Gynaecologist 2021;23:9–20.

 

3.3.7 More from HEE on genomics in oncology

Website – Genomics Education Programme

https://www.genomicseducation.hee.­nhs.uk/genomics-in-healthcare/genomics-in-oncology/

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Get in touch

Thank you for visiting our Genomics hub. If you have any questions about genomics at the RCOG or feedback about this hub, please email fpradhan@rcog.org.uk.